Effect of quercetin on nonshivering thermogenesis of brown adipose tissue in high-fat diet-induced obese mice
نویسندگان
چکیده
Activating nonshivering thermogenesis in brown adipose tissue (BAT) is a promising strategy to prevent obesity. This study investigated whether quercetin supplementation improves obesity mice by increasing BAT and white (WAT) browning. Compared high-fat diet (HFD)-fed mice, fed HFD supplemented with 1% (HFDQ) had reduced body weight total plasma cholesterol. In HFDQ-fed retroperitoneal WAT (RWAT) was decreased, browning effect lipolysis were increased. increased expression of genes BAT, including uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor-gamma coactivator 1? (PGC1?), cell death-inducing DFFA-like effector A (CIDEA), mitochondrial transcriptional factor (mtTFA). Quercetin proteins ?3-adrenergic receptor (ADRB3), p38 mitogen-activated kinase (MAPK), AMP-activated (AMPK) pathways HFD-fed which suppressed an AMPK inhibitor or ADRB3 antagonist. Energy expenditure core temperature not changed quercetin, but physical activity HFDQ during dark periods at room cold temperatures. also decreased the Firmicutes Bacteroidetes ratio short-chain fatty acid production feces mice. summary, may attenuate Although did show consistency data molecular pathophysiological levels between function obesity, it shows health effects accompanied improved gut microbiota dysbiosis.
منابع مشابه
Brown adipose tissue thermogenesis in obese animals.
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ژورنال
عنوان ژورنال: Journal of Nutritional Biochemistry
سال: 2021
ISSN: ['0955-2863', '1873-4847']
DOI: https://doi.org/10.1016/j.jnutbio.2020.108532